Figures 5A and B show immunohistochemical images of FKBP10 and S1PR4 in different differentiation states. The immunohistochemical results showed that the expression level of oncogene FKBP10 was negatively correlated with the degree of differentiation, while the expression of tumor suppressor gene S1PR4 was the opposite. In addition, this study used immunohistochemical images of tissues at different stages to demonstrate that the expression level of FKBP10 gradually increased with increasing tumor stage, and that of S1PR4 gradually decreased with increasing tumor stage (Figures 5C, D). The gene discussed is S1PR4; the disease is neoplasm.