Among them, the highest node degree target gene is EGF (upregulated in MS), which is an epidermal growth factor that binds to receptors on the cell membrane and activates the PI3K-Akt signaling pathway (63), and as mentioned earlier, inhibition of the “PI3K-Akt signaling pathway” is essential for MS treatment. The gene discussed is AKT1; the disease is myeloid sarcoma.