JAK1 and COVID-19: Related to this, a recent non-randomized open-label study evaluated the complementation with inhaled DNase plus tocilizumab and baricitinib (JAK1/2 inhibitor), finding association with lower in-hospital mortality and intubation rate, shorter duration of hospitalization, and prolonged overall survival; in addition, in an in vitro approach, plasma from those COVID-19 patients undergoing the complemented treatment induced less tissue factor/thrombin pathway in primary lung fibroblasts as compared to standard-of-care (64).