Recently, it has been reported that in the context of COVID-19, dexamethasone can downregulate interferon-stimulated genes and activated IL-1R2+ in neutrophils, and to expand immunosuppressive immature neutrophils (54), thus the mechanism by which dexamethasone can diminish neutrophil activity is by affecting their functions toward a immunosuppressive phenotype. This evidence concerns the gene IL1R2 and COVID-19.