This molecule, IgG, seems to play an important role in regulating osteoclastogenesis: IgG immunocomplexes are generally considered an important pathway leading to bone destruction in rheumatoid arthritis by driving the differentiation of human blood monocytes into a nuclear factor of activated T-cell cytoplasmic 1 (NFATc1)-negative non-classical osteoclasts and RANKL-induced classical osteoclasts (56). This evidence concerns the gene TNFSF11 and rheumatoid arthritis.