HAVCR2 and glioblastoma: Given that TIM-3 and LAG-3 are expressed in tumor-infiltrating lymphocytes functioning as coinhibitory receptors that could induce immune exhaustion in the microenvironment of GBM (46, 47), researchers applied a combination of anti-TIM3 + anti-PD1 + focal radiation as well as anti-LAG3 + anti-PD1 in murine models, and the survival was significantly prolonged (48, 49).