R223C/H change was reported in one case of LGG and one case of GBM, and missense mutation of LIGHT was discovered to be the most common type of genetic alteration (Figure 9B), inducing a frameshift mutation of the LIGHT gene that switched residue 223 of the protein from R (arginine) to C (cystine) or H (histidine), followed by LIGHT protein truncation. The gene discussed is TNFSF14; the disease is glioblastoma.