In the TCGA dataset, we found an obviously negative correlation between LIGHT expression and tumor purity in both LGG (Figure 6A, R = -0.6295, P = 2.403e-41) and GBM (Figure 6B, R = -0.3241, P = 4.809e-6), indicating that LIGHT expression might increase the complexity of gliomas. The gene discussed is TNFSF14; the disease is central nervous system cancer.