More specifically, the thorough analysis of LIGHT’s roles in tumor-cell interactions suggested a positive relationship between LIGHT expression and infiltrating cells like monocytes, M1 macrophages, neutrophils, DCs, CD8+ T effector memory cells (TEM), CD4+ TEM cells, and NK cells, while a negative relationship was found in pro-B cells, CD8 naive T cells, Th1 cells, and plasma cells. This evidence concerns the gene TNFSF14 and neoplasm.