Residual tumor size (P=0.018), residual involved nodes (P<0.001), tumor Ki-67 (P<0.001), serum SDF-1 at baseline (P=0.046), serum SDF-1 at surgery (P<0.001), and TILs at surgery (P<0.001) were significant predictors of DFS and entered the multivariate Cox regression model with forward selection. This evidence concerns the gene CXCL12 and neoplasm.