For inhibition of the recruitment of TAMs, the CCL2/CCR2 axis barricade which is has been found to be helpful in a mouse ovarian cancer model (34), and disrupting the CXCL12/CXCR4 axis which prolongs the survival of a tumor mouse model (35) seem to be an encouraging therapy. The gene discussed is CXCR4; the disease is ovarian carcinoma.