The SUV intensities were reduced in the tumor-bearing rats receiving the combination of CTLA-4-PD-L1-I DNA and Protein vaccines or Protein vaccine alone in week 43 (Figures 2A, B), suggesting suppression of tumor growth, which correlated with the increased CTLA-4 and PD-L1 antibody titers as shown in Figures 1C and D. This evidence concerns the gene CTLA4 and neoplasm.