IL22 and cancer: This influences the colon microbiome, through the secretion of IEC antimicrobial peptides, thus inhibiting cancer formation (25).These results are in line with the discovery that ILC3s and gamma delta T cells (Tγδ) must produce IL-22 to effectively initiate the DNA damage response (DDR) in the intestinal epithelial stem cells in order to control mutations that lead to carcinogenesis.