CASP8 and neoplasm: Moreover, purified human ILC3s, isolated from peripheral blood or non-cancerous human liver tissue of healthy donors, can kill human melanoma cells (SK-Mel-37) and promote anti-tumor immune response, due to the recognition of tumor cells by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)/TRAILR2, which activates Caspase-8 in target cells and interferon gamma (IFN-γ) secretion, inducing cell cytotoxicity (37) (Figure 2).