Furthermore, it has been found that infiltrating numbers of NKp44+ILC3s and tertiary lymphoid structures (TLS) negatively correlate with colorectal tumor progression (32), NKp44+ILC3s decrease whereas ILC1 and NKp44-ILC3s increase during tumor formation which might be indicating a plasticity from NKp44+ ILC3s to ILC1 (27, 32) as it has been found intermediate cellular states between the two subpopulations (27). This evidence concerns the gene NCR2 and colorectal neoplasm.