The zinc finger and BTB domain containing 7B (Zbtb7b, Alias ThPOK) as transcription factors can upregulate sperm tail PG-rich repeat containing 1 (STPG1) and downregulate Tumor necrosis factor receptor superfamily member 12A (TNFRSF12A) at the transcriptional level, inhibiting the proliferation of gastric cancer cells and promoting the proliferation of T cells (27, 28). Here, TNFRSF12A is linked to gastric cancer.