Calmodulin 2 (CALM2) in GC promotes M2 polarization of macrophages through the Adenylate kinase 2 (AK2)/Signal transducer and activator of transcription 3 (STAT3)/HIF-1/vascular endothelial growth factor A (VEGFA) axis, thereby promoting GC metastasis and angiogenesis (11). This evidence concerns the gene AK2 and gastric cancer.