POU class 1 homeobox 1 (POU1F1) upregulated by High mobility group A 1B/2 (HMGA1B/2) promotes GC metastasis by regulating macrophage M2 polarization in a Chemokine 12 (CXCL12)/CXC motif chemokine receptor type 4 (CXCR4) dependent manner (9). The gene discussed is POU1F1; the disease is gastric cancer.