CD103+ CD4+ T cells exhibit an immunosuppressive phenotype and high retention capacity in GC tumor tissues, leading to CD8 + T cell dysfunction, and granzyme B (GZMB), interferon-γ (IFN-γ), tumor necrosis factor α (TNF-α), and perforin (PRF-1) reduction (21). The gene discussed is TNF; the disease is gastric cancer.