STING1 and gastric cancer: Interestingly, the knockdown of STING in THP1 cell line or activation of STING via 2’3’-c-GAMP were shown to promote M1 polarization of macrophages and exert an anti-tumor effect, suggesting that the STING pathway has complex and meaningful regulatory roles in macrophages (13).In gastric cancer, macrophages can induce the transformation of mesenchymal stem cells (MSC) cells into fibroblasts, and then participate in the formation of immune tolerance (14).