However, the instability of Foxp3+ Treg cells in colitis has been identified, and multiple studies have demonstrated that the expression of Foxp3 in Treg cells isolated from inflammatory sites decreased, indicating a loss of Foxp3 expression (40), which may explain why the proportions of Treg cells increased in colitis mice, while the expression of Foxp3, Il10 and Tgfb1 decreased. Here, FOXP3 is linked to colitis.