The infiltration of TILs into tumor tissue to kill tumor cells has been studied in two areas (1): TIL CD8 cells should have intact signaling molecules after harvesting TILs from tumor tissue (4–6, 80), and (2) how ex vivo-cultured TILs specifically enter tumor tissue from circulating blood after reinfusion (81). The gene discussed is CD8A; the disease is neoplasm.