MYC and neoplasm: To further investigate the influence of tumor secreted apoE on immune cell function, immunogenic B16 tumor cells (B16 cells treated with Myc inhibitors (0.25μM BET+0.25μM JQ1 for 4 days) were irradiated at 60 Gray and co-cultured with naïve C57/BL6 splenocytes in the presence of either apoE mimetic COG133 at 0.3, 3 and 9 μM or anti-APOE blocking antibody at 1, 10 and 30 μg/ml concentrations.