Fourteen out of 23 detectable cytokines were significantly upregulated when splenocytes were co-cultured with Myc-inhibited B16 tumor cells, including effectors: IFNγ, TNFα; stimulators, IL18, G-CSF, M-CSF; inflammatory factor: IL6; chemo attractive factors: CCL-5 (Rantes), CXCL-1, CCL-2, CCL-7, CXCL-2, CCL3; and regulatory factors: IL-10, IL6 (P < 0.05). This evidence concerns the gene IL18 and neoplasm.