Also known as family with sequence similarity 26, member F (FAM26F), it was identified as a TLR signaling-derived membrane molecule that plays an important role in various immune responses. The expression of FAM26F has been shown to be altered in a wide range of viral, bacterial, and parasite infections, pathophysiological illnesses, and cancers, according to several research (44). This evidence concerns the gene CALHM6 and parasitic infectious disease.