Also known as protein kinase R (PKR), responsible for the regulation of protein synthesis by phosphorylating the translation initiation factor eIF2α of serine-51, the eIF2α kinase PKR can regulate both global and specific mRNA translation in response to a variety of different stimuli, in particular in the immune response (34). EIF2AK2 selectively regulates immune responses and transcription of SLE-related histone genes (35). The gene discussed is EIF2AK2; the disease is systemic lupus erythematosus.