Among them, the genes with more obvious PPI interactions are Irf7, Stat1, Rsad2, Eif2ak2, Usp18, Isg15, Ddx58, Ifit1, Uba7, Ifit3, Ifi44, Ifih1, which have nodes with high degree of interaction and can be used as key candidate genes, with innate immune memory, may be more critical in the pathogenesis of SLE. This evidence concerns the gene IFI44 and systemic lupus erythematosus.