AGE-modified bovine serum albumin downregulated the expression of NRP-1, which may be achieved by reducing the binding ability of the Sp1 transcription factor to the NRP1 promoter to the inhibit the transcriptional activity of the NRP1 promoter in podocytes (71), thus restraining podocyte migration, which leads to increases in “nude” areas of the glomerular basement membrane adhesion to the Bowman space and causes glomerulosclerosis (70). This evidence concerns the gene NRP1 and glomerulosclerosis.