Melanoma differentiation‐associated protein 5 (MDA5), as a receptor for recognition of congenital pathogens, induces interferon synthesis, which impairs β-cell insulin production, proinsulin transformation, and mitochondrial function (105) and may recognize RNA of RNA-based COVID-19 vaccines, thus promoting the development of T1DM (92, 106) (Figure 3). This evidence concerns the gene INS and COVID-19.