All in all, our results shed light on the complex pathophysiology of SARS-CoV-2, focusing on the S protein given its wide utilization in vaccination strategies, and despite the current limitations of this study, the findings presented are nevertheless important, providing an insight into how the S protein alters the cellular milieu and transcriptomic profile, in order to establish an optimal cellular environment for viral infection and production. The gene discussed is PROS1; the disease is viral infectious disease.