PROS1 and infection: Given the inevitable involvement of tissue macrophages in the phagocytosis of vaccine particles, in this study, we were curious as to what transcriptomic changes may occur in monocyte-derived macrophages 5 hours post-transfection with the SARS-CoV-2 S protein, result of which may perhaps unravel its pathologic role in infection, and provide data on its effects as part of vaccination platforms.