Interestingly, the abnormal up-regulation of some classical PTPs was associated with CNV gain such as PTPRA in rectum adenocarcinoma (READ) (Rs = 0.81, FDR< 1.68 × 10-32) and PTPN2 in UCS (Rs = 0.74, FDR< 5.53 × 10-9), and some abnormal down-regulations were associated with CNV loss such as PTPN23 in UCS (Rs = 0.66, FDR< 8.23 × 10-7) and PTPRS in OV (Rs = 0.53, FDR< 5.78 × 10-19) (Figure S1E). The gene discussed is PTPN23; the disease is reading.