Receptor tyrosine kinases (RTKs) are a subclass of tyrosine kinases that are involved in mediating cell-to-cell communication and controlling a wide range of complex biological functions, including cell growth, motility, differentiation, metabolism and immune responses (2, 3).Dysregulation of RTK signaling leads to many human diseases, especially cancer, making these proteins promising drug targets for cancer therapy (4). Here, NTRK1 is linked to cancer.