Therefore, the next experiment was conducted to evaluate whether the expression levels of TLR3, RIG-I, and MDA5, and the activation of NF-κB and IRF3 are deficient or delayed in RV 16-infected or poly (I: C)-treated inflammatory epithelial cells which were derived from patients with CRSwNP. This evidence concerns the gene NFKB1 and chronic rhinosinusitis with nasal polyps.