To explore whether the decreased expression of IFN-β, -λ1, -λ2, and ISGs in patients with CRSwNP can enhance the replication of RV 16 in inflammatory epithelial cells of patients with CRSwNP, we evaluated RV 16 replication rates in normal and inflammatory sinonasal epithelial cells from normal control and patients with CRSwNP. Here, IFNB1 is linked to chronic rhinosinusitis with nasal polyps.