In contrast, tumor growth was better controlled and mice survival was significantly improved in the groups that received anti-PDL1-dimHLE, or anti-CD73/PDL1-HLE, in addition to the 14D5-dimHLE biologic, suggesting at least that the beneficial effects of anti-PDL1-dimHLE, and of anti-CD73/PDL1-HLE are maintained in the presence of the P2X7-potentiating biologic. The gene discussed is NT5E; the disease is neoplasm.