As the 14D5-dimHLE biologic does not promote beneficial effects when used alone, we next evaluated whether potentiation of P2X7 can enhance anti-tumor immune responses when combined with immunogenic oxaliplatin chemotherapy, that may increase the release of ATP in the tumor, or with anti-immune checkpoints therapy, or antagonism of CD73 involved in the formation of the immunosuppressive adenosine. Here, NT5E is linked to neoplasm.