We validated here, prior to the tumor inoculation, that the blocking or the potentiating P2X7-specific biologics were produced in vivo and were able to completely block P2X7 (i.e., for the 13A7-hcAb biologic) or to potentiate its activity notably at low ATP concentration, (i.e., for the 14D5-dimHLE construct) (Figure 1, and data not shown). This evidence concerns the gene P2RX7 and neoplasm.