ADCYAP1 and migraine disorder: While migraine evidently is a neurovascular condition it seems that certain rosacea features such as flushing, and the neurogenic stinging and burning are attributed to neurovascular alteration and upregulation of signaling neuropeptides such as calcitonin-gene-related peptide and pituitary adenylate cyclase-activating polypeptide-38 (9, 14–17).