Combined IPA and KEGG network comparative analyses between mild and moderate/severe disease patients identified downstream pathways, previously implicated in ALD pathology literature: IGF‐1 dysfunction has been observed in both neonatal and early childhood (noncerebral) ALD patient fibroblasts30 and in reduced insulin signaling in the ABCD1‐KO mouse spinal cord.31 This evidence concerns the gene IGF1 and adrenoleukodystrophy.