Combined IPA and KEGG network comparative analyses between mild and moderate/severe disease patients identified downstream pathways, previously implicated in ALD pathology literature: IGF‐1 dysfunction has been observed in both neonatal and early childhood (noncerebral) ALD patient fibroblasts30 and in reduced insulin signaling in the ABCD1‐KO mouse spinal cord.31 The gene discussed is IGF1; the disease is X-linked adrenoleukodystrophy.