TARDBP and amyotrophic lateral sclerosis: One of the first common links between PPIs for SMA and ALS was described in 2017 where survival motor neuron 1 (SMN1) and the ALS-associated proteins FUS RNA binding protein (FUS), TAR DNA binding protein 43 (TDP43) and senataxin (SETX) were identified as shared components with the RNA metabolism network (38).