One of the first common links between PPIs for SMA and ALS was described in 2017 where survival motor neuron 1 (SMN1) and the ALS-associated proteins FUS RNA binding protein (FUS), TAR DNA binding protein 43 (TDP43) and senataxin (SETX) were identified as shared components with the RNA metabolism network (38). Here, SETX is linked to amyotrophic lateral sclerosis.