Interactome analyses of the ALS-associated proteins FUS, EWS RNA binding protein 1 (EWSR1), TAT-box binding protein associated factor 15 (TAF15) and matrin-3 (MATR3) revealed a common association with the U1 snRNP assembly network as well as the RNA polymerase II network (39). This evidence concerns the gene FUS and amyotrophic lateral sclerosis.