TMEM258 and asthma: We briefly illustrate an example of a GReX-PheWAS using three genes (Figures 4, S15, and S16; Table S6): TAF7, a novel gene in our TWAS, and ILRAP18 and TMEM258, two genes previously implicated through GWASs.60, 61, 62, 63, 64 These genes were prioritized from European-specific TWASs for asthma risk from the flagship GBMI project using lung tissue expression (101,311 cases and 1,118,682 controls): TAF7 (MOSTWAS model), IL18RAP (JTI model), and TMEM258 (JTI model).