It was reported that mLP-CRISPR achieved 44% indel formation at the VEGFA loci, resulting in a 35% decrease in VEGFA expression levels in the RPE-choroid-scleral (RCS) tissues of C57BL/6J mice, and 63% reduction of the choroidal neovascularization (CNV) area in the laser-induced wet AMD mice. Here, VEGFA is linked to wet macular degeneration.