Other genetic causes of Lissencephaly include mutations in ARX playing an important role in forebrain development (Gécz et al., 2006), RELN which encodes the protein reelin (Hong et al., 2000) and other genes like KIF2A, KIF5C, CDK5, VLDLR, ACTB, ACTG1, and TUBG1 (Parrini et al., 2016) which, however, have not been properly modeled so far. The gene discussed is RELN; the disease is lissencephaly spectrum disorders.