During epilepsy, astrocytes and microglia are activated and TNF-α, IL-6, IL-1β proinflammatory factors were released, and these inflammatory factors constantly activate inflammatory signal pathways such as neurons, glial cells, blood brain barrier, etc., such as NF-KB, COX2, etc., and finally cause extensive biological effects (van Vliet et al., 2018). This evidence concerns the gene IL1B and epilepsy.