Evidence has suggested that Fcgr2b is closely associated with arthritis-related joint pain (Bersellini Farinotti et al., 2019), anterior cingulate cortex and prefrontal cortex alteration after nerve injury (Poh et al., 2012; Zhang et al., 2022), and stroke in aged rats (Buga et al., 2012). The gene discussed is FCGR2B; the disease is arthritic joint disease.