BDNF and prion disease: Among these 11 pathways, the most affected pathways were the Wnt signaling pathway and Axon Guidance (20 miRNAs up-regulated and 16 downregulated), PI3K-Akt signaling pathway (20 up- and15 downregulated), GABAergic synapse and TGF-beta signaling pathway (19 up- and 14 downregulated), Jak-STAT signaling pathway (19 miRNAs downregulated), circadian entrainment (13 miRNAs downregulated) and circadian rhythm (16 upregulated), Prion diseases (9 upregulated and 9 downregulated), Hedgehog signaling pathway (only 18 upregulated), Neurotrophin signaling pathway (only 20 miRNAs upregulated).