Miao et al. (2021), identified miR-4284 as an anticancer in colon cancer. It inhibits colon cancer tumorigenesis by reducing PLIN5 and inhibiting EMT. Thus, miR-4284 could be a potential therapeutic target in metastatic colon cancer. Another miRNA that resulted downregulated is miRNA-203a-5p. This miRNA is predicted to be implicated in the regulation of ERK1 («miRDB» database) (Vanacore et al., 2017; Cossu et al., 2019). Here, MAPK3 is linked to colonic neoplasm.