Another study of adults admitted to 11 different ICUs with sepsis demonstrated that patients with higher ([TIMP-2]× [IGFPB7]/1000) values early in their course were more likely to develop persistent AKI (non-recovery at 3 days) but that the short term changes in the biomarkers over the first 24 h failed to similarly identify at risk patients (105). This evidence concerns the gene TIMP2 and acute kidney injury.