Of the patients with confirmed CHIKV infection, only arthralgia (OR: 3.391, 95% CI: 1.430–8.044, 0.0089) and elevated AST (OR: 2.688, 95% CI: 1.124–6.430, p = 0.0412) were significantly associated with anti-CHIKV seropositivity (IgM+ or IgG+) (Table 1). Here, CD40LG is linked to Arthralgia.