Jiang T et al. reported a child with generalized epilepsy carried a heterozygous missense mutation of RYR2 [c.14767A > T/p.(Met4923Leu)], showing abnormal sinus arrhythmia, ventricular extrasystoles, and paroxysmal ventricular tachycardia (32). This evidence concerns the gene RYR2 and Paroxysmal ventricular tachycardia.