RYR2 and catecholaminergic polymorphic ventricular tachycardia: However, Lehnart SE et al. reported that a heterozygous p.R2474S mutation of RYR2 gene could cause seizures in mice, independent of cardiac arrhythmias, which is the first time to reveal the association of RYR2 with epilepsy, independent of CPVT (16).