RYR2 and idiopathic generalized epilepsy: Jiang T et al. reported a child with generalized epilepsy carried a heterozygous missense mutation of RYR2 [c.14767A > T/p.(Met4923Leu)], showing abnormal sinus arrhythmia, ventricular extrasystoles, and paroxysmal ventricular tachycardia (32).