Compared to those in the proteinuria <100 mg/kg/24 h group, the patients in the proteinuria ≥100 mg/kg/24 h group had lower serum albumin levels, a higher incidence of hypoalbuminemia, and a higher proportion of M1 among pathological changes and were more likely to receive methylprednisolone pulse and tacrolimus (P < 0.05). The gene discussed is ALB; the disease is Hypoalbuminemia.