ANXA5 and Alzheimer disease: Recently, it was found that choroid plexus annexin A5 levels were decreased in AD patients in the late stage of the disease, accompanied by increased Aβ levels and cell death, and that CSF annexin A5 levels were increased, indicating that annexin A5 is able to protect choroid plexus cells from Aβ-induced autophagic injury and apoptosis (Bartolome et al., 2020).