Considering that sensory transduction through the VNO proceeds via a G-protein-coupled mechanism (Berghard and Buck, 1996), our data showed that a high number of G-protein coupled receptor genes (GPR39, GPR65, GPR18), as well as genes which modulate (RGS10, GPSM3, PLEK) or inhibit (PSAPL1) the G-protein signalling activity, are differentially expressed among comparisons, especially between sex-separated vs. sex-combined female adults (SF vs. CF) (Supplementary Data 3; Figure 4). The gene discussed is PSAPL1; the disease is cystic fibrosis.