Decreased neuronal density has been shown in the cerebral cortices of MS patients (Vercellino et al., 2005, 2009; Bevan et al., 2018) and pyramidal neuronal loss (annexin V, encephalopsin, NeuN, and Thy1-YFP) has also been shown multiple times in chronic EAE (Mangiardi et al., 2011; MacKenzie-Graham et al., 2012b; Burns et al., 2014; Stanojlovic et al., 2016), highlighting that cortical pathology is important in this MS model as well. This evidence concerns the gene ANXA5 and myeloid sarcoma.