CD4 and myeloid sarcoma: MS targets myelin antigens of CNS, involving CD4 + and CD8 + cells, and also, during progressive MS, the role of B cells appears to be prominent, particularly in the context of meningeal inflammation, the formation of ectopic germinal centers, including B cells, was found in the meninges of patients with progressive MS, indicating that the adaptive immune system plays an important role in the pathogenesis [27].The inflammatory response in MS is the cumulative effect of a series of factors, their mediators, and effector molecules, such as cytokines and antibodies [28].