VAI: visceral adiposity index, PCOS: polycystic ovarian syndrome, LH: luteinizing hormone, FSH: follicle stimulating hormone, SHBG: sex hormone binding globulin, DHEAS: dehydro-epiandrosterone, OGTT: oral glucose tolerance test, AFC: antral follicle count, HOMA-IR: homeostatic model assessment of insulin resistance, FAI: free androgen index. The gene discussed is PLOD1; the disease is Insulin resistance.