In the current study, we determined the expression of FXR in colon cancer and its role in the deterioration of colon cancer, and we further explored its target gene DHRS9 and analyzed DHRS9-associated oxidative phosphorylation mechanism, thus to provide a more sufficient theoretical basis for FXR/DHRS9 regulating the progression of colon cancer. The gene discussed is DHRS9; the disease is colonic neoplasm.