ALDH2 and atrial fibrillation: This might be related to the absence of habitual alcohol consumption in ALDH2∗2/∗2 carriers because of the negligible activity of ALDH2. Thus, abstaining from alcohol consumption could prevent the development of AF in patients who are ALDH2∗1/∗2 allele carriers in the Japanese population.PerspectivesCOMPETENCY IN MEDICAL KNOWLEDGE: Alcohol—a risk factor for AF—is metabolized by ALDH2. Dysfunctional alleles of the ALDH2 (ALDH2-deficient variants) are prevalent among East Asians.