HPSE and neoplasm: This analysis revealed that tumor size (pT3+pT4) [7.81 (95% CI 1.78–34.12, p = 0.006)], pTNM advanced stages (III and IV) [3.48 (95% 1.09–11.14, p = 0.035)], and barely lymphovascular invasion and HPSE1 expression were prognostic factors of the presented OSCC cohort.