HPSE and lip and oral cavity carcinoma: Our data suggest a link between the expression of HPSE1 and its potential as a prognostic marker for OSCC and shed light on our understanding of the biology for oral cancer progression, such as evidence for the action of HPSE1 in inhibiting apoptosis, promoting proliferative signaling, regulating MMP expression and EMT to facilitate invasion and establishment of the pre-metastatic niche, and increasing the bioavailability of pro-angiogenic factors.