Interestingly, 7 out of the 21 protein-coding genes studied here (RAC1, ITPR1, PLCB1, CACNA1C, PLOD2, CCND2, DNMT3A) are causative of inherited monogenic diseases when germinally mutated in humans, and all of them (with the possible exclusion of SACM1L), result to be deregulated in several types of human cancers when somatically mutated. This evidence concerns the gene CACNA1C and cancer.