Regarding the reproductive system, three of these genes (UBE2N, PPP2R1B and ACVR2A) have been shown to be involved in reproductive disfunctions in humans (polycystic ovary syndrome and transsexuality, azoospermia, and susceptibility to preeclampsia, respectively (Fitzpatrick et al., 2009; Dong et al., 2021; Du et al., 2021). This evidence concerns the gene UBE2N and Azoospermia.