Interestingly, 7 out of the 21 protein-coding genes studied here (RAC1, ITPR1, PLCB1, CACNA1C, PLOD2, CCND2, DNMT3A) are causative of inherited monogenic diseases when germinally mutated in humans, and all of them (with the possible exclusion of SACM1L), result to be deregulated in several types of human cancers when somatically mutated. The gene discussed is SACM1L; the disease is cancer.