PGAM1 and type 1 diabetes mellitus: Because circRNA could regulate the gene expression by interacting with miRNA, we also constructed the circRNA-miRNA-gene network diagram and the results indicated that the signaling hsa_circ0005630-miR-1247-5p-ATXN1/ARL6IP1 and hsa_circ0007026-miR-324-5p-NCAPD2/PGAM1 might be involved in the progression of T1DM (Figure 6).