In an animal study using disrupted-in-schizophrenia 1 (DISC1) knockout (KO) mice as an animal model of schizophrenia, we found a reduction in the number and fiber length of NPY-immunoreactive (NPY-IR) neurons in the prefrontal cortex of DISC1 KO mice, suggesting that DISC1 dysfunction may be involved in the pathogenesis of schizophrenia through impairment of the NPY neural network (29). The gene discussed is DISC1; the disease is schizophrenia.