These two GO terms can contribute to pathological processes, including abnormal phosphorylation of tau protein (Chidambaram et al., 2020; Wegmann et al., 2021), deposition of Aβ (Guimaraes et al., 2021), over-activation of microglia (Haque et al., 2018), and dysregulation of calcium homeostasis (Sushma and Mondal, 2019), in AD pathogenesis through various downstream kinases, such as GSK-3β, CDK-5, and ERK signaling cascade. Here, CDK5 is linked to Alzheimer disease.