PRKN and Alzheimer disease: Interestingly, PINK1/Parkin tagging of mitochondria for degradation appears to be upregulated in the brain of AD patients as reflected by both higher total protein levels and higher association with mitochondria in late stage AD; this might potentially reflect an attempt to compensate for the dysfunctional or inefficient mitophagy (Ye et al., 2015; Martín-Maestro et al., 2016).