SOD1 and amyotrophic lateral sclerosis: Evidence supporting increased mitophagy resulting from ALS-associated SOD1 mutations includes increased p62 recruitment to the mitochondria suggesting increased mitochondrial priming, decreased levels of mitochondrial proteins suggesting lower levels of mitochondria, and, most convincingly, increased mitophagy as demonstrated by the mt-Keima reporter in SOD1 mutant mice (Palomo et al., 2018).