For example, the identification of SREBF-1, a previously known risk locus for sporadic PD, in a screen for genes that regulate PINK1/Parkin mediated mitophagy highlights mitophagy dysfunction as a shared mechanistic link between autosomal recessive PD and at least some cases of sporadic PD (Ivatt et al., 2014). The gene discussed is PINK1; the disease is Parkinson disease.