For example, the identification of SREBF-1, a previously known risk locus for sporadic PD, in a screen for genes that regulate PINK1/Parkin mediated mitophagy highlights mitophagy dysfunction as a shared mechanistic link between autosomal recessive PD and at least some cases of sporadic PD (Ivatt et al., 2014). This evidence concerns the gene PRKN and Parkinson disease.