TDP-43 colocalizes with mitochondrial markers in spinal cord and brain tissue from ALS patients and in patient-derived fibroblast lines containing TARDBP mutations, suggesting a potential mechanism by which TDP-43 could affect mitochondrial function (Wang et al., 2016; Wang P. et al., 2019). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.