PINK1 and Parkinson disease: For example, mutations in PINK1 and Parkin are associated with early-onset forms of Parkinson’s Disease (PD) (Borsche et al., 2021; Vizziello et al., 2021) while mutations in MFN2 are associated with axonal forms of Charcot-Marie-Tooth disease 2 (CMT2) and hereditary motor and sensory neuropathies (HMSN) (Zaman and Shutt, 2022).