Importantly, the C-terminal fragments resulting from proteolytic cleavage of TDP-43 are found in TDP-43 cytoplasmic inclusions, while exogenous expression of hTDP-43 in mice results in ALS-like motor phenotypes including tremors, difficulty walking, and abnormal hindlimb clasping in addition to cytoplasmic TDP-43 aggregates in spinal cord motor neurons (Shan et al., 2010; Xu et al., 2010; Jun et al., 2020). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.