ADAMTS6 expression was downregulated, as shown by RNA-seq and validated by qRT-PCR, in adipose-derived stem cells undergoing osteogenesis and a genome wide association study (GWAS) identified ADAMTS6 as a promising, but not yet genome-wide significant, susceptible loci for osteosarcoma (Savage et al., 2013; Shaik et al., 2019). This evidence concerns the gene ADAMTS6 and osteosarcoma.