Because both PD-L1 expression (Taube et al., 2014) and TIL abundance (Haanen, 2017) are positive predictors for the response to immune checkpoint inhibitors (ICIs), the upregulation of Syk, Lck, STAT5, and Caspase-7 could indicate a better immunotherapeutic response in HCC patients. Here, SYK is linked to hepatocellular carcinoma.