We found several oncogenes or tumor suppressor genes whose mutations were associated with reduced antitumor immunity in HCC, including TTN, TP53, CTNNB1, RB1, and ZFHX4. Among them, TP53 and RB1 are famed tumor suppressor genes (Sherr and McCormick, 2002). Here, ZFHX4 is linked to hepatocellular carcinoma.