APOBEC3A and pancreatic adenocarcinoma: Our study found that APOBEC3A/3G/3H are also highly expressed in PAAD tissues, and the APOBEC3A/3G/3H gene itself can be amplified and mutated, which leads to an increase in the expression levels of APOBEC3A/3G/3H, resulting in uncontrolled deamination of the cellular genome.