The genetic variations in the ATP13A2 (ATPase type 13A2), PLA2G6 (phospholipase A2, group VI), and FBXO7 (F-box only protein 7) genes result in atypical parkinsonism, which are recessively inherited (Shen et al., 2018) Considering the fact that phenotypic traits genes have expanded new technologies for identifying the scope of both monogenic and risk-related PD (next-generation sequencing (NGS), genome-wide association studies (GWAS), the approaches that can be used to modulate these genes becomes quite important in PD (Grenn et al., 2020; Tan et al., 2021). This evidence concerns the gene ATP13A2 and Parkinson disease.