Although abnormal or excessive levels of the protein α-synuclein can induce neurodegeneration in PD, lowering the expression of its genes LRRK2, PINK1, and VPS35 may help prevent progressive neurodegeneration (Figure 1) and hence may slow down further progression of the disease (Srinivasan et al., 2021). The gene discussed is VPS35; the disease is Parkinson disease.